The
functional depression which is a
consequence of the morphologic alterations seen in the
brain-cells may be due to the low blood-pressure which follows
excessive trauma is shown by the experiments. The
circulation of animals was first rendered STATIC by over-transfusion, and was controlled by a
continuous blood-pressure
record on a drum. In each of the instances, morphologic changes in the cells of all parts of the
brain were found, but it required much more
trauma to
produce brain-
cell changes in animals whose blood-pressure was kept at the
normal level than in the animals whose blood-pressure was allowed to take a downward course. In the cortex and in the
cerebellum, the changes in the
brain-cells were in every
instance more
marked than in the medulla.